ЭВОЛЮЦИОННОЕ РАЗВИТИЕ И СТРУКТУРНОЕ РАЗНООБРАЗИЕ ПРИРОДНЫХ АНТИМИКРОБНЫХ ПЕПТИДОВ, ПЕПТИДОМИМЕТИКОВ И КАТИОННЫХ АМФИФИЛОВ НА ОСНОВЕ АМИНОКИСЛОТ

  • МАРИЯ КОНСТАНТИНОВНА ГУСЕВА Институт тонких химических технологий им. М.В. Ломоносова, РТУ МИРЭА
  • СВЕТЛАНА МИХАЙЛОВНА ФИЛАТОВА Институт тонких химических технологий им. М.В. Ломоносова, РТУ МИРЭА
  • ТАТЬЯНА ГЕННАДЬЕВНА БОДРОВА Институт тонких химических технологий им. М.В. Ломоносова, РТУ МИРЭА
  • ДАРЬЯ ВАСИЛЬЕВНА ПАРШИНА Институт тонких химических технологий им. М.В. Ломоносова, РТУ МИРЭА
  • УЛЬЯНА АЛЕКСАНДРОВНА БУДАНОВА Институт тонких химических технологий им. М.В. Ломоносова, РТУ МИРЭА
  • ЮРИЙ ЛЬВОВИЧ СЕБЯКИН Институт тонких химических технологий им. М.В. Ломоносова, РТУ МИРЭА
Ключевые слова: резистентность, АМП, пептидомиметики, катионные амфифилы, антибактериальная активность, минимальная ингибирующая концентрация

Аннотация

В обзорной статье прослеживаются основные тенденции синтетического подхода к решению вопроса преодоления резистентности патогенных штаммов бактерий. Приведены основные стратегии поиска перспективных агентов, начиная с природных антимикробных пептидов или пептидов «защиты человека», с последующим эволюционным переходом к синтетическим пептидомиметикам макромолекулярного или олигомерного типов, а также подхода, основанного на мембранно-активных низкомолекулярных катионных амфифилах.  Показано структурное многообразие пептидомиметиков с высокой бактерицидной активностью, обладающих повышенной устойчивостью к действию протеолитических ферментов по сравнению с природными пептидами. Большое внимание уделено различным алифатическим и ароматическим катионным амфифилам на основе аминокислот. Отмечены потенциальные возможности этого класса соединений в качестве антимикробных агентов. Амфифильная структура синтезированных соединений позволяет им избирательно воздействовать на бактериальные мембраны и не приводит к запуску у бактерий процесса развития резистентности.

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Опубликован
2021-08-19
Как цитировать
ГУСЕВА, М., ФИЛАТОВА, С., БОДРОВА, Т., ПАРШИНА, Д., БУДАНОВА, У., & СЕБЯКИН, Ю. (2021). ЭВОЛЮЦИОННОЕ РАЗВИТИЕ И СТРУКТУРНОЕ РАЗНООБРАЗИЕ ПРИРОДНЫХ АНТИМИКРОБНЫХ ПЕПТИДОВ, ПЕПТИДОМИМЕТИКОВ И КАТИОННЫХ АМФИФИЛОВ НА ОСНОВЕ АМИНОКИСЛОТ. Российский химический журнал, 65(2), 22-34. https://doi.org/10.6060/rcj.2021652.2
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